Ibutamoren (MK-677) Review

Searching for ways to improve performance and results in the gym is extremely exciting for fitness enthusiasts because there are so many different types of substances that can enhance a person’s output. A downside to this wealth of riches, however, is that it is increasingly difficult to wade through all the choices and decipher what each one is, and whether or not they are safe. Ibutamoren is just such an option, and with it being referenced under the names MK-677 and Nutrobal, it is easy to see how confusion is possible. More specifically, MK-677 is a growth hormone secretagogue, which is essentially a fancy phrase describing the process of secretion that has been induced by another substance. But at its core, what is Ibutamoren, and how can it help those who ingest it orally?

The History Of Ibutamoren And What It Is

Reverse Pharmacology is the center at which MK-677 was first introduced, with its main focus being to trigger the pituitary gland to secrete, or ‘release,’ growth hormone. Like most substances created from a lab, their initial intentions and goals differed. Originally Ibutamoren was to be a way to produce positive reactions for a myriad of health issues including muscle wasting, osteoporosis, and even obesity. Secretagogues can be responsible for allowing insulin to release as well.

What Do The Studies Say?

mk-677 studies on IGF-1

416 patients treated with 25 mg dose of MK-677 for 12 months in a double-blind, multicenter study. Result: Serum IGF-1 levels increased 60.1% at 6 weeks and 72.9% at 12 months.

Though early in the testing phase, there is no doubt that the initial feedback has been overwhelmingly positive. Trials of the orally administered substance displayed a direct correlation between its use and a spike in IGF-1. Insulin growth factor is beneficial for a multitude of health related ailments because it has healing properties. MK-677 has been proven to help the cutting phase for ardent muscle builders, and has encouraged healthier sleep patterns. The strengthening of bone density has also been present in numerous cases.

Why Bodybuilders Love Ibutamoren?

MK-677 is a SARM, which is a selective androgen modulator receptor. SARMs are frequently discussed in weightlifting forums because they are a viable alternative to anabolic steroids. While effective in muscle growth, steroid use diminishes yearly because their side effects can cause long term damage. This includes irritating the prostate, shrinking the testes, and in extreme cases, enlarging the heart. SARMs mimic the output of anabolic steroids, while cutting back the dangers dramatically. Selective androgen modulator receptors are able to accomplish this successfully by not affecting every tissue inside us. Instead, as their name states, they only instigate change in certain areas, namely muscles. Lean body mass is greatly coveted by people who workout, and those who have tried MK-677 state that it delivers this goal combined with a diet plan seamlessly.

How Can This SARM Help Me Specifically?

1. Ghrelin receptors (GHSR) are critical to growth hormone escaping from the brain.

Ibutamoren’s duty in this process is to bind to a GHSR receptor and copy its intended effect. The aftermath is your body utilizing an abundance of this hormone without substantially increasing other hormones. It is a game changer in the fitness world because it does not alter cortisol. This is pertinent to those that take MK-677 because it will not block the immune system from quick recovery times

2. MK677 Has no effect on Cortisol Profiles

[eckosc_quote quote=”Nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677…for 7 consecutive days…MK-677 had no effect on cortisol profiles. In particular, 24-h mean levels of plasma total and free cortisol and urinary excretion of free cortisol were similar under all conditions.” source=” Center for the Study of Biological Rhythms, Universit√© Libre de Bruxelles, Belgium.” url=”” pull=”false”]

3. Ibutamoren bars somatostatin receptors.

These receptors inhibit growth hormone from releasing in larger quantities. When somatostatin receptors are not allowed to disrupt growth hormone, it amplifies the production of GHSR. This is desired for a wealth of positive actions within the body like increasing size gain and the ability to attain lean muscle mass, the healing of tendons and ligaments at a swifter rate, and oxidizing fat more efficiently. The fact that brittle bones can regenerate dramatically proves why it has been linked to treatment of osteoporosis.

What Are The Side Effects Of Ibutamoren?

It is fortunate that MK-677 does not mimic anabolic steroids in what they leave behind, which in most cases are enlarged organs, and even destruction to the liver. Instead, the only drawback seems to be a bigger appetite. This is not a surprising sidebar to taking Ibutamoren, as GHSR is linked to signaling hunger in the brain. Taking Ibutamoren can also spark incessant dreaming, similar to over the counter melatonin.

What Are The Doses Of MK-677 And When Do You See Results?

Various schools of thought have placed the dose range from 10mg a day up to as much as 50mg, but the jury is still out on the ideal region for maximizing its effects. Users have cited an uptick in endurance at lower dosage levels. You can burn fat with relative ease without ingesting too much in a 24 hour period.

The levels of IGF increase dose dependently, so it stands to reason that if your end game is more solid muscle, a higher dose is essential. The logical starting point is beginning low, and working your way up until you find what you are looking for as far as impact. Users typically show positive change in a month, with fat burning starting to occur within a couple of weeks.

How To Get The Most Out Of MK-677

Growth hormone is one of the safer components of your body to stimulate. But that does not provide a pass for carelessness. MK-677 is at its best with you keep a steady routine. A well balanced diet paired with working out on a moderate regiment is enough to deliver unequivocal results. The key to Ibutamoren is not abusing the doses and maintaining a consistent game plan for your body.


Because Ibutamoren has limited side effects, and provides several intriguing avenues to improve a person’s physique, it is a solid addition to any fitness buff’s regiment. With a routine of hard work and recommended doses, it is one of the most rewarding SARMs on the market in a reasonable price range.

Where Can I Buy MK-677?

Common sense and discipline should always be at the forefront of your purchase decision. Especially when it comes to acquiring any supplement you consume. As such, if you have any reason for pause or concern, contact the distributor to have them put any potential fears you have to bed. SARMS1 is the most trusted sarms provider in the market at this moment.

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